Prof. Dr.-Ing. Carmen Constantinescu graduated “Mechanical Engineering” at Technical University of Cluj-Napoca, Romania and accomplished the PhD in “Industrial Engineering” area, followed by MBA studies in Management at the same university. Since 2001 she is working at Fraunhofer Institutes IPA and IAO in Stuttgart. In 2008 Prof. Constantinescu founded the department “Digital Factory” and currently is leading the research area “Digital Manufacturing4.0”. Prof. Constantinescu is involved in academic activities at University of Stuttgart, Royal Institute of Technology, Sweden and Technical University of Cluj-Napoca, Romania, in areas of Modelling, Simulation, Digital/Virtual and Smart Factory. More than 30 research projects financed by European Commission; German Ministry of Research and Education, German National Science Foundation, and German industry; more than 4 Books, 30 scientific publications represent the contribution to the academic and industry communities. Prof. Constantinescu is involved in norming and standardization activities of the Association of German Engineers (VDI), contributing since 2007 for the elaboration of norms in the field of Digital Factory, Modelling and Simulation, IT-Platforms and for Digital Factory. On European level, she acts as expert of the European Commission, providing active support to the evaluation process for the Research frameworks FP6, FP7 and Horizon2020.